Have you ever been in a tight parking spot where you are barely able to open your door to get out without bumping the car next to you?  Imagine trying to function daily in a kitchen, bathroom, bedroom, ect... where you can barely maneuver the wheelchair without hitting the leg rests or your knuckles on the surrounding household furniture, cabinets, walls, ect... 
When a house is not designed to meet a person's spatial requirements giving them no leeway, it can lead to frustration and injuries.   
Spatial relationships to take into consideration are hallway width, clear door opening, roll under width, distance between furniture and cabinetry, ect...
People using a wheelchair will need to be able to turn around and this requires a minimum area of clear floor space that is specific to the type of chair they are using and their ability to maneuver it.  The design of the room needs to allow for a "T" or  "U" type of turnaround.

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Spatially Integrated Housing
Harvest Construction LLC